Winter APIs For Pharmacies: DXM+Guaifenesin

Nasty Winter Symptoms

When winter comes, everything gets cold: the air, the wind, the dampness, even the flu.

The winter flu would keep you coughing all through the night if you had been there, till you felt you were coughing your lungs out, and it still wouldn’t stop.

This type of cough is known as the dry cough.

What is worse, it seemed impossible for you to get rid of the phlegms on your throat, and you had a stuffy nose, one nostril was running water and finally was through, but the other was still stuffed, and the two nostrils kept switching positions to make you uncomfortable.

coughings caused by flu in winter
running noses caused by Flu in winter

What would you do?

You would go to your doctor and ask for some meds that would help you to relieve your damn man-killing cough.

nine times out of ten, your doctor would write down some prescriptions with Dextromethorphan Hydrobromide tablets along with Guaifenesin tablets.

You would go home and take the meds as prescribed and your coughing symptoms were greatly relieved, even your throat was feeling better, and no more that much phlegm stuck in your throat.

In 2 to 3 days, you were feeling much better, and finally, you were well again.

So what are those two miraculous ingredients anyway?

What Is Dextromethorphan?

Dextromethorphan hydrobromide. with Cas Number 6700-34-1, also known and abbreviated as DXM or DXM HBr, is the active pharmaceutical ingredient used widely as an effective cough suppressant.

Its pure powder is in the form of white crystals and with a faint odor.

It is a hydrate with a water content of 3.5%~5.5% regulated by the current USP.

DXM is contained in my OTC cold and cough medicines.

It only suppresses the coughs by easing the coughing center in the brain, but won’t cure the cold or flu, and it is the same case for Guaifenesin.

DXM is not supposed to be used against chronic coughs caused by smoking and asthma.

It is also combined with Bupropion hydrochloride to treat patients with major depressive disorder as a fast-active antidepressant.

chemical structure of dextromethorphan hydrobromide hydrate
DXM HBr Hydrate 6700-34-1 Chemical Structure

Product Name: DXM HBr (氢溴酸右美沙芬一水合物)

Appearance: A white crystalline powder

Cas Number: 6700-34-1

Molecular Formula: C66H102N17O16S

Molecular Weight: 1421.69 g/mol

Chemical Name: (1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[,10.02,7]heptadeca-2(7),3,5-triene;hydrate;hydrobromide

HS Code: 2933990099 (Other heterocyclic compounds containing only nitrogen heteroatoms-其他仅含氮杂原子的杂环化合物)

chemical structure of Guaifenesin API 93-14-1
Guaifenesin 93-14-1 Chemical Structure

Product Name: Guaifenesin (愈创甘油醚)

Appearance: A white powder

Cas Number: 93-14-1

Molecular Formula: C10H14O4

Molecular Weight: 198.22 g/mol

Chemical Name: 3-(2-methoxyphenoxy)propane-1,2-diole

HS Code: 2909499090 (Other ether alcohols and their derivatives-其他醚醇及其衍生物)

What Is Guaifenesin?

Guaifenesin, also known as glyceryl guaiacolate, is a white to off-white powder.

It is the side-kick for DXM to ease the annoying cough as an expectorant.

The major function of guaifenesin is to get rid of phlegms stuck in the airways.

It relieves chest congestion by thinning the thick mucus to make it easier to be coughed out.

However, guaifenesin will not either cure the cold or speed up the recovery process, it is just a temporary relief from the coughs and congested chests, which means, it just makes the recovery process easier, not shorter or faster.

The time for your recovery still depends on your immune system.

Besides its efficacy on coughs, guaifenesin is also a muscle relaxant widely used in large-animal veterinary surgery along with xylazine.

How Much Does DXM HBr API Cost?

For compounding pharmacists who are GMP-Approved Dextromethorphan Hydrobromide Hydrate, please check our cost break-down and price ideas below:

1 KG DXM our price is 450 USD without shipping cost.

5 KG DXM our cost is 400 USD per KG

If you can order 25 KG, our price can be 320 USD/KG

Normally our MOQ starts at 1 KG, so we only indicated our prices from 1 KG.

Feel free to contact us for a quote for other quantities out of the quantity range above.

In case you need quantities less than 1kilo, feel free to contact us any time and we will arrange it accordingly.

What Are DXM Dosage Forms?

DXM can be compounded into many dosage forms, with or without guaifenesin.

We have listed some of the dosings for your ref below:

  1. Dextromethorphan Hydrobromide Syrups: 10ml: 15mg
  2. Dextromethorphan Sustained-release Suspension: 100ml:0.6g
  3. Dextromethorphan Hydrobromide Tablets: 15mg
  4. Dextromethorphan Hydrobromide Sustained-Release Tablets: 30mg
  5. Dextromethorphan Hydrobromide Oral Solution: 10ml:15mg
  6. Dextromethorphan Hydrobromide Granules: 15mg
  7. Dispersible Guaifenesin and Dextromethorphan Hydrobromide Tablets: DXM 15mg/Guaifenesin 100mg
  8. Dextromethorphan Hydrobromide and Guaifenesin Syrup: 1.5mg DXM/ml+10mg guaifenesin/ml
  9. Dextromethorphan Hydrobromide Chewable Tablets: 5mg
  10. Dextromethorphan Hydrobromide Soft Capsules: 15mg

This list goes on and it proves one point: DXM is widely used and compounded into many dosage forms as medications for coughing.

No matter what season it is, we hope all of you guys who saw this post can stay healthy and never have to take any meds. 

Peace and Love!

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